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Berkson (2017) published a case report, discussing a 64-year-old male patient diagnosed with metastatic renal cell carcinoma that despite nephrectomy and the standard oncological protocols (bevacizumab, sunitinib and sorafenib) continued to worsen with a left lung metastasis.
He was given IV Therapy with Vitamin C 25 to 50 g every morning and IV Therapy with R+ α-lipoic acid (ALA) 300 to 600 mg every afternoon. When he started these he was was in very weak, and cachectic.
The oral protocol included LDN 4.5 mg at bedtime, and "the oral Triple Antioxidant Therapy protocol" with R+ ALA, selenomethionine and silymarin along with a B complex with hydroxycitrate (HCA) added later to the protocol.
He experienced rapid improvement and continued the IV ALA infusions twice a week and IV vitamin C twice a week and then transitioned to every 3 months for a week or two of intensive daily IV vitamin C and IV ALA therapy.
Ultimately, the patient had stable disease with disappearance of the signs and symptoms of stage IV RCC, a full 9 years following diagnosis.
See our IV ALA section for more details.
IV Alpha Lipoic Acid and IV Vitamin C are both mechanically complemented by Hyperbaric Oxygen Treatment. Hyperbaric treatment complements the IV ALA and IVC through metabolic and oxidative mechanisms respectively.
A case report from Riordan described a 70-year-old white male diagnosed with metastatic Kidney Cancer. He began Vitamin C IV Therapy treatment, starting at 30 grams twice per week. Six weeks after initiation of therapy his metastases were shrinking. The patient remained cancer-free for 14 years and he died of congestive heart failure at the age of 84.
Another case report from Riordan a 51-year-old woman with left kidney tumor, with lung metastasis as who declined standard therapy began 65 g twice per week for 10 months, with oral supplements. Within 8 months of Vitamin C IV Therapy, the chest X ray was clear, and kidney was in remission. The patient was diagnosed 4 years later with a new primary lung cancer, and died of lung cancer not kidney cancer.
See our Edmonton IV Vitamin C section for more details.
In the same case report as the final renal cancer case described above, 49-year-old man denied standard therapy after resection of bladder tumor and satellite tumors. He received 30 g of vitamin C IV Therapy twice per week for 3 months, followed by 30 g once every 1–2 months for 4 years along with oral supplements. 9 years after diagnosis, the patient is in good health with no symptoms of recurrence or metastasis. In one report only 20% of patients with invasive bladder cancer treated only with surgery remained free of recurrent disease after 3–7 years of follow-up.
In a series of case reports from 2003, "The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer," describes two patients with Stage III advanced ovarian cancer. 60g intravenous vitamin C was administered twice weekly complimentary to carboplatin/ paclitaxel chemotherapy. In addition both patients took oral anti-oxidant supplements.Both patients had remained disease free at the time of publication. One patient had been followed for 3.5 years, the other patient for 3 years. As mentioned above, it's thought that the oxidative action of IV Vitamin C can be enhanced by Hyperbaric Oxygen treatment.
2011 clinical trial evaluated the safety of Vitamin C IV Therapy combination treatment in patients with stage III or IV ovarian cancer using carboplatin–paclitaxel and the patients receiving IV Vitamin C Therapy experienced a lower incidence of toxicities in most categories. This study was not powered to test efficacy, but the addition of IV Vitamin C to chemotherapy showed a trend toward improved survival and delayed disease progression.
Data from Medicor cancer centre indicated a high degree of response to metabolic treatment of Ovarian cancer with 7/10 Ovarian patients having a response. Metabolic treatments are mechanistically enhanced with Hyperbaric Chamber treatments. Our Naturopaths have seen declinations in CA-125 using IV Alpha Lipoic Acid and Ketogenic diets in our Edmonton patients.
Cervical intraepithelial neoplasia (CIN; also called cervical dysplasia) is a precancerous change in the epithelium of the uterine cervix of which there are awesome naturopathic options to help with.
Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and Brussels sprouts that our Naturopathic doctors use a ton of in our Edmonton clinic.
In a double-blind trial, supplementation with I3C induced complete regression of lesions in approximately 50% of women with CIN II or CIN III.
Occasionally our Naturopathic doctors see advanced Cervical cancer at our Edmonton office.
A case report exists where Paclitaxel and IVC produced transient stable disease with increased energy and strong functional improvement with a marked reduction in tumor-related leg edema - Stable disease was documented after two months on the Vitamin C IV Therapy protocol despite previous progression when the same chemotherapy was given much more frequently.
At this point the patient chose to discontinue the paclitaxel injections entirely and requested IV Vitamin C therapy alone; After a total 175 days of IVC therapy a CT scan showed local disease progression.
IV Therapy with Vitamin C has particular relevance as Cervical cancer is thought to has a viral component and the anti-viral properties of Vitamin C in addition to its oxidative effects are thought to be pertinent. The effect of IV Vitamin C is thought to be enhanced by Hyperbaric Oxygen treatment.
Lymphoma, Myeloma, Leukemia
IV Therapy with Vitamin C is of particular relevance: A case report with a 66 year old woman with B-cell lymphoma (7X11cm mass). The patient had 5 weeks of radiation, along with IVC and declined chemotherapy. She also took oral supplements.
She received 15 g of vitamin C twice per week for about 2 months, 15 g once to twice per week for about 7 months, and then 15 g once every 2–3 months for about 1 year.
Patient took IV Vitamin C Therapy from January 1995 to December 1996, at which time the patient was in normal health and had no clinical sign of lymphoma.
Case report data from Anderson showed benefit in a Lymphoma patient with a metabolic approach which is thought to be enhanced by Hyperbaric Therapy. Multiple Myeloma and CLL were discussed as benefiting from this protocol as well. Our Naturopathic doctors have seen benefit from adding oral enzymatic therapy to Myeloma patients as well as well as IV Lipoic Acid therapy to CLL.
In "Long-term stabilization of metastatic melanoma with sodium dichloroacetate," which is a metabolic therapy paired with Lipoic Acid IV Therapy. A 32-year-old male is presented with no concurrent conventional had regression and stabilization of recurrent metastatic melanoma for over 4 years’ duration. Although we do not do DCA therapy at our office other metabolic treatments such as IV Therapy with Lipoic Acid and possibly Hyperbaric Oxygen may be of benefit.
Wormwood which is another therapy our Naturopaths work with has a handful of case reports in Uveal melanoma. This is an oxidative treatment that might be enhanced by Vitamin C IV Therapy and Hyperbaric Treatment.
A 2017 clinical trial assessing IV Vitamin C in combination with radiation and temozolomide chemotherapy in Glioblastoma multiforme ("GBM" - an aggressive Glioma). Average overall survival was 21.5 months (median was 18.2 months) versus the historical median of 14 months
Another case of a woman with glioblastoma who lived for over four years from diagnosis experiencing good quality of life for most of that time. She underwent initial debulking craniotomy, radiotherapy and chemotherapy, as well as having intravenous vitamin C infusions 2–3 times weekly over the four years from diagnosis.
Our Naturopathic Doctors always integrate metabolic approaches (eg. Ketogenic diets and IV Alpha Lipoic Acid) with regards to brain cancers like GBM in our Edmonton patients along with Oxidative treatments like IV Vitamin C.
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